Efficacy and tolerance of ultra high dose rate synchrotron irradiation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591840
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: OKAMOTO Yoshiaki 神戸大学, 医学(系)研究科(研究院), 講師 (20362791)
• Co-Investigator(Kenkyū-buntansha): SASAKI Ryohei 医学部付属病院, 特命教授 (30346267) ; YOSHIDA Kenji 神戸大学, 医学部附属病院, 特命講師 (80351906) ; MIYAWAKI Daisuke 医学(系)研究科(研究院), 助教 (30546502) ; FURUSE Motomasak 大阪医科大学, 医学部, 講師 (70340560)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 放射光 / Mirobeam / Spring-8

Outline of Final Research Achievements

This study was prformed at Spring-8, Hyogo Japan, using synchrotron radiation.
Normal tissue tolerance to ultra-high dose rate radiation was examined using C57/BL6 mice brain in vivo. The comparison between broad beam and several slit beams irradiation revealed that a LD50 of slitbeam (500 Gy)achieved approximately 7-folds higher than that of broad beam(70 Gy). Moreover, the slit beam irradiation did not cause severe neuronalcells loss. The slit beam irradiation to the brain did not induce abnormal behavior disorder in mice. The slit beam irradiation to the spinal cord did not cause any difference to that of broad beam irradiation.

Free Research Field

放射線腫瘍学