Prediction of late rectal bleeding treated with radiotherapy for prostate cancer using biochemical marker.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591846
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Sapporo Medical University
• Principal Investigator: SOMEYA Masanori 札幌医科大学, 医学部, 講師 (60404711)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 放射線直腸炎 / 前立腺癌 / 放射線治療 / 有害事象予測

Outline of Final Research Achievements

To predict individual radiosensitivity of normal tissue, we collected and analysed the expressions of Ku80 mRNA and radiation-induced microRNA-99a in peripheral blood lymphocytes treated with radiotherapy for prostate cancer. Peripheral blood lymphocytes were collected from 97 prostate cancer patients with at least 3 year of follow-up after radiotherapy. As a result, a combination of low Ku80 mRNA expression and highly-induced microRNA-99a could precisely detect grade 2 or more of radiation-induced late rectal bleeding. In conclusion, a combination of low Ku80 expression and highly-induced microRNA-99a expression could be a promising marker for predicting rectal bleeding after radiotherapy.

Free Research Field

放射線腫瘍学