呼気中一酸化窒素測定による胸部放射線治療後放射線肺臓炎の早期発見・治療効果判定

2015 Fiscal Year Annual Research Report

• Project/Area Number: 24591848
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: 山崎 秀哉 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (50301263)
• Co-Investigator(Kenkyū-buntansha): 坪倉 卓司 京都府立医科大学, 医学(系)研究科(研究院), 助教 (50347465) [Withdrawn] ; 小林 加奈 高知大学, 医学部附属病院, 講師 (70433282) [Withdrawn] ; 相部 則博 京都府立医科大学, 医学(系)研究科(研究院), 助教 (50739240) ; 中村 聡明 京都府立医科大学, 医学(系)研究科(研究院), 講師 (60420452) [Withdrawn]
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 放射線肺臓炎 / 放射線治療 / 肺がん

Outline of Annual Research Achievements

We analyzed the levels of exhaled nitric oxide (eNO) and serum surfactant protein D (SP-D) during and after 34 thoracic radiotherapy (RT) sessions in 33 patients. We measured eNO levels before RT, every week during RT, just after the treatment, and 1, 3, 6, 9, and 12 months after the treatment. The therapy reduced the eNO from 24.3 ppb ± 12.8 ppb before RT to 19.0 ± 10.4 ppb just after RT (p = 0.04). Five patients (14%) developed symptomatic RP of grade 2 or higher, 3 - 5 months later, with an elevation in the eNO ratio of 2.1 ± 0.68-fold the minimum value. The RP-negative group showed up to 1.4 ± 0.6-fold elevation (p = 0.02). No predictive changes in eNO levels were observed before the onset. RT elevated serum SP-D level at 3 - 6 months after RT. There was a statistically significant difference between previous serum SP-D level between RP positive and negative patients.