2016 Fiscal Year Final Research Report
Novel diagnostic tool for drug-induced liver injury after liver transplantation
| Project/Area Number |
24591861
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
Takeda Ikuo 東北大学, 医学系研究科, 大学院非常勤講師 (90420033)
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| Project Period (FY) |
2012-04-01 – 2017-03-31
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| Keywords | 薬剤性肝障害 / 肝臓移植 / 遺伝子多型 / 薬剤代謝遺伝子 |
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| Outline of Final Research Achievements |
We colected blood, urine, and liver tissue samples at fixed intervals after liver transplantation. DNA was extracted from frozen liver tissue, and RNA was extracted from lymphocyte cells obtained from blood samples. Using the DNA and RNA, Genetic polymorphism related to drug metabolism was analyzed using SNP (single nucleotide polymorphism) analysis. The association of genetic polymorphism with drug hepatopathy will be assessed when enough number of samples are accumulated.
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| Free Research Field |
肝臓移植
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