Innovation with living donor liver transplantation by introducing MSCs for small-for-size graft

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591878
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Kyoto University
• Principal Investigator: OGAWA Kohei 京都大学, 医学(系)研究科(研究院), 助教 (10359789)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 間葉系幹細胞 / 肝移植 / 部分肝移植 / 肝再生

Outline of Final Research Achievements

We have shown that the "MSCs are effective for ameliorating liver ischemia-reperfusion injury after hepatectomy", "MSCs are effective in improving recipient survival after prolonged preservation of graft." Based on these data, we evaluated the effect of MSCs with prolonged preservation of partial graft mimicking clinical cadaveric split liver transplantation. However, we could not show the benefit in terms of recipient survival. As histology of the liver showed necrosis and AST and ALT are elevated with MSCs group, MSCs may have detrimental effect such as thrombus formation secondary to cell aggregation. Conditioned medium from MSC culture would be evaluated hereafter.

Free Research Field

消化器外科、臓器移植