Development of air way xenotransplant graft with extracellular matrix and cytokine

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591881
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Kagawa University
• Principal Investigator: GO TETSUHIKO 香川大学, 医学部附属病院, 講師 (50313656)
• Co-Investigator(Kenkyū-buntansha): MATSUURA Natsumi 香川大学医学部, 附属病院, 助教 (20572853) ; KASAI Yoshitaka 香川大学医学部, 附属病院, 助教 (40610085) ; YOKOMISE Hiroyasu 香川大学, 医学部, 教授 (80231728)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 再生医学 / 気道再建 / 異種移植 / 人工材料

Outline of Final Research Achievements

We investigated the novel tissue material for airway repair. Pig trachea was decellularised by detergent - enzymatic method treatment into extracellular matrix (ECM) which was confirmed non-antigenicity. Patch material made from this ECM was applied as xenotransplant tissue graft to repair air way defect made on dog’s cervical trachea. ECM patch graft derived from pig was incorporated in heterologous host of dog without immunosuppression and air way defect was restored successfully. On the other hand, applying cytokines such as erythropoietin, G-CSF did not improve epithelialization on the ECM graft, which needs to be investigated further.

Free Research Field

医歯薬学