Reprograming of mouse acini induced by EGFR receptor ligands

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591893
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Clinical research Center, Chiba-East National Hospital, National Hospital Organization
• Principal Investigator: ASANO Takehide 独立行政法人国立病院機構(千葉東病院臨床研究センター), その他部局等, その他 (80143311)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 再生医療 / 幹細胞 / 可塑性 / 遺伝子発現

Outline of Final Research Achievements

Beta-cell replacement is a promising therapy for type 1 diabetes. But shortage of pancreas donor is serious problem in Japan . Many reports has been existed about success of induction beta-cell from embryonic stem cells or induced pluripotent stem cells (iPS), however risk of teratoma formation is obstacle for clinical application.
Here we show EGFR receptor ligands can dedifferentiate pancreatic acini derived from adult mice. Nestin positive cells can be obtained and they show stem cell like characters.

Free Research Field

再生医学