The development of the system estimating realtime antitumor activity of activated T lymphocytes in cancer immunotherapy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591908
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Kyushu University
• Principal Investigator: MORISAKI Takashi 九州大学, 医学(系)研究科(研究院), 共同研究員 (90291517)
• Co-Investigator(Kenkyū-buntansha): ONISHI Hideya 九州大学, 大学院医学研究院, 准教授 (30553276) ; KATANO Mitsuo 九州大学, 大学院医学研究院, 教授 (10145203) ; IMAIZUMI Akira 九州大学, 大学院医学研究院, 共同研究員 (30624051)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: random migration / 運動能 / 活性化リンパ球 / 細胞障害活性 / バイオマーカー / 治療効果予測 / FTYP

Outline of Final Research Achievements

In activated T lymphocytes, velocity of random migration increases than resting lymphocytes and it may contribute to cytotoxicity against cancer. Addition of phosphorylated FTY720 (FTYP) suppresses the velocity of random migration in activated T lymphocytes and it leads to the decrease in cytotoxicity against cancer. In addition, we confirmed tha antitumor effect by the administration of FTYP using in vivo mice model. These results suggest that random migration in activated T lymphocytes may become a useful biomarker for therapeutic effect of cancer immunotherapy.

Free Research Field

腫瘍免疫学