2015 Fiscal Year Final Research Report
Novel mechanism and molecular targeted therapy of thyroid cancer
| Project/Area Number |
24591919
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Chubu University |
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Principal Investigator |
TAKEDA Kozue 中部大学, 生命健康科学部, 准教授 (80345884)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMOTO Yoshiyuki 中部大学, 生命健康科学部, 准教授 (10410664)
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Masashi 名古屋大学, 医学系研究科, 教授 (10281073)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | チロシンキナーゼ / RET / がん |
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| Outline of Final Research Achievements |
We previously demonstrated that a specific cysteine residue is crucially involved in regulation of RET kinase activity. In this study, we successfully inhibited the oncogenic RET kinase activity through the cysteine mediated novel regulation mechanisms and suppressed the malignancy of RET expressed tumor cells.
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| Free Research Field |
分子生物学
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