2014 Fiscal Year Final Research Report
Spreading immune-reactions in esophageal cancer patients who were given cancer vaccine and whose tumors co-express additional antigens
| Project/Area Number |
24591939
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Mie University |
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Principal Investigator |
KAGEYAMA Shinichi 三重大学, 医学(系)研究科(研究院), 教授 (80194695)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | がんワクチン / 食道癌 |
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| Outline of Final Research Achievements |
Clinical trials of cancer vaccine, including CHP-MAGE-A4 protein vaccine and CHP-NY-ESO-1 protein vaccine, were conducted for esophageal cancer patients. Tumor samples were analyzed for tumor antigen expressions. Serum samples of pre-vaccine and post-vaccine time points were analyzed for protein microarray reactions and ELISA of MAGE-A4 and NY-ESO-1 antigens. We assessed immune-spreading phenomenon across other antigens that were not immunized.
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| Free Research Field |
臨床腫瘍学
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