2014 Fiscal Year Final Research Report
Identification of novel drug-response determinants in esophageal squamous cell carcinoma
| Project/Area Number |
24591952
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Oita University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TSUKAMOTO Yoshiyuki 大分大学, 医学部, 助教 (00433053)
SHIBATA Tomotaka 大分大学, 医学部, 助教 (20566905)
FUMOTO Shoichi 大分大学, 医学部, 客員研究員 (00532631)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | テイラード医療 / 効果予測システム / マイクロアレイ / 抗癌剤 / 食道癌 |
|---|
| Outline of Final Research Achievements |
A novel statistical analysis, a two-dimensional mixed normal model, provided 3 (CARD8, TMUB2, and EMX2) and 6 candidates (C10orf97, CCDC90B, IFITM1, TARBP1, TTYH2, and MARK1) respectively for 5-FU and CDDP, as novel sensitivity marker genes in esophageal cancer. And we developed highly predictive formulae in vitro and in vivo using expression data of a set of the all selected marker genes.
|
| Free Research Field |
医歯薬学
|
