The study of novel prognostic marker and therapeutic target in esophageal squamous cell carcinoma patients

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591954
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kagoshima University
• Principal Investigator: OKUMURA Hiroshi 鹿児島大学, 医学部・歯学部附属病院, 講師 (10398282)
• Co-Investigator(Kenkyū-buntansha): ISHIGAMI Sumiya 鹿児島大学, 医歯学総合研究科, 准教授 (90325803) ; NATSUGOE Shoji 鹿児島大学, 医歯学総合研究科, 教授 (70237577) ; UCHIKADO Yasuto 鹿児島大学, 医学部・歯学部附属病院, 特例准教授 (30464465)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 食道癌 / 癌遺伝子 / 予後因子 / 治療ターゲット

Outline of Final Research Achievements

CYHR1 (cysteine/histidine-rich1) was first discovered in a yeast two-hybrid screen with murine galectin-3, and there have been no previous reports of a relationship between the CYHR1 gene and human cancer. The present study evaluated the role and significance of CYHR1 in esophageal cancer. CYHR1 is associated with proliferation, invasion and tumorigenicity in esophageal cancer cells. The expression of CYHR1 mRNA is associated with lymph node metastasis and stage, and it is an independent prognostic factor in patients with esophageal cancer. CYHR1 is not only a prognostic marker for esophageal squamous cell carcinoma patients but also a possible therapeutic target.

Free Research Field

腫瘍外科学