The study of the significance of the phosphorylation of p53 Ser46 in the prediction of response to preoperative chemotherapy or chemoradiotherapy for advanced esophageal cancer.

2015 Fiscal Year Final Research Report

• Project/Area Number: 24591962
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kinki University
• Principal Investigator: YASUDA Takushi 近畿大学, 医学部, 教授 (10324782)
• Co-Investigator(Kenkyū-buntansha): IMAMOTO Haruhiko 近畿大学, 医学部, 教授 (80351609) ; IMANO Motohiro 近畿大学, 医学部, 准教授 (00278681) ; SHINKAI Masayuki 近畿大学, 医学部, 講師 (80340793) ; YASUDA Atsushi 近畿大学, 医学部, 講師 (60351615) ; SHIRAISHI Osamu 近畿大学, 医学部, 講師 (70388536) ; IWAMA Mitsuru 近畿大学, 医学部, 講師 (20548648) ; KATO Hiroaki 近畿大学, 医学部, 講師 (30460900)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: p53-Ser-46 / 食道扁平上皮癌 / 治療効果予測 / リン酸化誘導 / バイオマーカー / アポトーシス

Outline of Final Research Achievements

In this study, we examined the usefulness of induction of the phosphorylation of p53-Ser46 the next day after initiation of treatment as a biomarker of the prediction of treatment response of chemotherapy/chemoradiotherapy for esophageal squamous cell carcinoma. We confirmed the fact for the first time that the phosphorylation of p53-Ser-46 was induced by chemotherapy/chemoradiotherapy in the early stage of treatment. However, there was no significant correlation between the phosphorylation of p-53-Ser-46 and treatment response. Among cases obtained complete response to preoperative therapy, the cases with p-53 mutant and no induction of Ser-46 phosphorylation were involved, therefore, these results suggested that the effect on chemotherapy and chemoradiotherapy was caused not only by apoptosis thorough p53 pathway, but also by another pathway associating with other factors.

Free Research Field

食道癌集学的治療