2014 Fiscal Year Final Research Report
Antitumor effect of a novel HSP90 inhibitor in esophageal cancer cells
| Project/Area Number |
24591964
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAOMOTO Yoshio 川崎医科大学, 医学部, 教授 (00237190)
FUKAZAWA Takuya 川崎医科大学, 医学部, 講師 (20379845)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 食道外科学 |
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| Outline of Final Research Achievements |
We investigated the antitumor effects of a novel HSP90 inhibitor, AUY922, in esophageal squamous cancer cells (ESCC). Four ESCC cell lines (TE-1, TE-4, TE-8, TE-10) were examined. AUY922 inhibited the proliferation of ESCC, particularly in PTEN-null TE-4 cells with a 2-3 times lower IC50 than the other cell lines. Western blot analysis showed that PTEN-null TE-4 cells showed higher Akt activity, which contribute to cell proliferation and survival. AUY922 suppressed the activity of Akt in TE-4 but not in PTEN-proficient TE-10 cells. AUY922 exhibits a strong antiproliferative effect, revealing its potential as a novel therapeutic alternative to current ESCC treatment. The effect may be improved further by impeding PTEN expression.
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| Free Research Field |
医歯薬学
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