2014 Fiscal Year Final Research Report
Identification of novel biomakers for predincting lymph node metastasis in colorectal cancer
| Project/Area Number |
24591979
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WAGURI Satoshi 福島県立医科大学, 医学部, 教授 (30244908)
IWADATE Manabu 福島県立医科大学, 医学部, 博士研究員 (00381393)
NAKAMURA Izumi 福島県立医科大学, 医学部, 准教授 (80423804)
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| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Shinya 福島県立医科大学, 医学部, 教授 (70251444)
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| Research Collaborator |
TACHIBANA Kazunoshin
ANDOH Jin
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 大腸癌 / リンパ節転移 / バイオマーカー |
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| Outline of Final Research Achievements |
The study aimed to identify novel biomarkers for personalized cancer management in colorectal cancer by a comprehensive gene expression analysis. We focused on two candidate genes that were obtained from analyses of our own microarray platform. The expression of those genes, including DPEP1 and TBX19, was upregulated in cancer tissues compared to non-cancer tissues. It is worth noting that they were significantly highly expressed in cancer tissues with lymph node metastasis. Their expression in protein levels was also confirmed in tumor specimens as well as colorectal cancer cell lines. In addition, immunohistochemical analyses demonstrated specific patterns of expression in tissues that were associated with clinicopathological characteristics, including tumor differentiation. Further analyses would be required to clarify the functional and clinical significance of these two genes, DPEP1 and TBX19, in colorectal cancer.
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| Free Research Field |
消化器外科学
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