2014 Fiscal Year Final Research Report
Therapeutic potential of the molecular targeting of PRL-3 and K-ras gene in colorectal cancer.
| Project/Area Number |
24591982
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | PRL-3 / K-ras / 大腸癌 / 予後 / リンパ節転移 |
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| Outline of Final Research Achievements |
(1) K-ras gene mutation was not correlated with staging factors in primary colorectal cancer, and it was recognized in about 40% of either primary or metastatic tumors.
(2) Clinicopathological analysis was performed for PRL-3 genomic amplification in 100 primary tumors of colorectal cancer, and 44 metastatic liver tumors of colorectal cancer. PRL-3 genomic amplification is more frequently recognized in poorly differentiated colorectal cancer, and cases with PRL-3 genomic amplification showed poorer prognosis than those without it.
(3) PRL-3 genomic amplification was significantly more frequently found in liver tumor of colorectal cancer than in the corresponding primary colorectal cancer.
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| Free Research Field |
大腸外科
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