2015 Fiscal Year Final Research Report
Elucidation of the graft senescence after pediatric living donor liver transplantatin by telomere length and telomerase using Q-FISH method.
| Project/Area Number |
24592013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Sanada Yukihiro 自治医科大学, 医学部, 助教 (60406113)
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| Co-Investigator(Renkei-kenkyūsha) |
Takubo Kaiyo 東京都長寿医療センター, 東京都健康長寿医療センター研究所, 研究部長 (00154956)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 肝細胞テロメア長 / 小児生体肝移植 / ドナー肝 / グラフト肝 / 加齢変化 |
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| Outline of Final Research Achievements |
This pilot study indicates that donor age is a crucial factor affecting telomere length sustainability in hepatocytes after pediatric LDLT, and that the telomeres in grafted livers may be elongated somewhat longer when the grafts are immunologically well controlled.
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| Free Research Field |
肝胆膵移植外科
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