Pharmaceutical treatment for abdominal aortic aneurysms in rats

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592064
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Kobe University
• Principal Investigator: OKADA Kenji 神戸大学, 医学(系)研究科(研究院), 研究員 (90284356)
• Co-Investigator(Kenkyū-buntansha): OKITA Yutaka 神戸大学, 医学(系)研究科(研究院), 教授 (40322193)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 大動脈瘤 / 薬物治療

Outline of Final Research Achievements

An ideal pharmaceutical treatment for abdominal aortic aneurysm (AAA) is to prevent aneurysm formation and development (further dilatation of pre-existing aneurysm). Recent studies have reported that oxidative stress with reactive oxygen species (ROS) is crucial in aneurysm formation. We have demonstrated that edaravone, a free-radical scavenger, attenuated vascular oxidative stress and inhibit AAA formation and development in rat AAA model. Based on the results, we also have proven the efficacy of other anti-oxidants, such as a gelatin hydrogel sheet incorporating ascorbic acid, a novel oral antidiabetic drug of Dipeptidyl peptidase-4 (DPP-4) inhibitor, and oral administration of riboflavin on the treatment of AAA.

Free Research Field

心臓血管外科