2015 Fiscal Year Final Research Report
Development of diagnostic method of metastatic malignant lesion and body lymph nodes use application of the fluorescence diagnosis of cancer.
| Project/Area Number |
24592079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SASAJIMA Tadahiro 旭川医科大学, 医学部, 名誉教授 (20109515)
OSAKI Yoshinobu 旭川医科大学, 医学部, 教授 (30191935)
HAYASHI Satoshi 旭川医科大学, 医学部, 助教 (10463754)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 肺悪性腫瘍 / 胸膜悪性腫瘍 / 光線力学的診断 |
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| Outline of Final Research Achievements |
Background: We conducted a study on photodynamic diagnosis (PDD) using autofluorescence in video-assisted thoracic surgery for intrathoracic small malignant lesion. In normal tissues, green autofluorescence of approximately 520 nm is observed in response to 400-450 nm blue excitation rays. However, in cancer lesions, green autofluorescence is reduced and the color spectrum thus shifts to red-violet. This phenomenon is the basis of PDD. Results: The color spectrum shift was observed in all tumors located on the pleural surface. Among patients with primary lung cancer, those with pleural infiltration (pl) scores of 1 or greater showed color spectrum shifts due to reduced autofluorescence. Conclusion: Localization of pleural lesions by autofluorescence imaging was found to be useful. In primary lung cancer cases, differentiation between pl0 and pl1 lesions appears to be useful for determining therapeutic strategies including surgical procedures.
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| Free Research Field |
胸部外科
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