2014 Fiscal Year Final Research Report
The efficacy of chitosan sheet covering for bronchial anastomosis wound healing in extracorporeal lung resection for lung cancer
| Project/Area Number |
24592085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WASEDA Ryuichi 金沢大学, 医学系, 協力研究員 (20579651)
WATANABE Go 金沢大学, 医学系, 教授 (60242492)
TAKIZAWA Masaya 金沢大学, 附属病院, 助教 (90612317)
ODA Makoto 金沢大学, 医学系, 准教授 (50224241)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 体外肺切除 / 肺癌 / 気管支創傷治癒 / キトサン / 肋間筋 |
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| Outline of Final Research Achievements |
Aim: We investigated the efficacy and safety of chitosan sheet covering for bronchial anastomosis wound healing in "extracorporeal lung resection (ECLR)" for lung cancer. Materials and methods: ECLR model was prepared and applied to dogs in control group (no covering), C group (chitosan sheet covering), and M group (intercostal muscle covering). Bronchial anastomotic site healing statuses were compared among the groups. Results: One dog of the control group died due to bronchial fistula accompanying empyema. All other dogs survived with no complication. C group had the highest recovery in tissue blood flow of bronchial anastomotic site, inflammation improvement of anastomotic site, and lung edema improvement on chest X-ray films. Granulation and angiogenesis around the anastomotic site were promoted the most in M group followed by C group and then the control group. Conclusion: For bronchial anastomosis wound healing in ECLR, chitosan sheet covering is safe and promotes wound healing.
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| Free Research Field |
呼吸器外科学
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