Development of regional brain hypothremia by trans-ventricular and trans-arterial cold infusion in acute cerebral ischemia

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592110
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Hokkaido University
• Principal Investigator: ABUMIYA Takeo 北海道大学, 医学(系)研究科(研究院), 特任助教 (80270726)
• Co-Investigator(Kenkyū-buntansha): HOUKIN Kiyohiro 北海道大学, 大学院医学研究科, 教授 (90229146) ; NAKAYAMA Naoki 北海道大学, 大学院医学研究科, 講師 (40421961)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脳梗塞 / 虚血再灌流 / 脳低温治療

Outline of Final Research Achievements

The present study initially confirmed that trans-arterial regional hypothermia possessed strong neuroprotective effects on ischemia-reperfusion (I/R) injury, and then demonstrated that the treatment sequentially inhibited the acute aquapolin4 (AQP4) surge, microvascular narrowing due to astrocytic end-foot swelling, endothelial dysfunction, and activation of inflammatory reactions. More direct and intensive cooling of the endothelium and its surroundings, including astrocytic end-feet, may contribute to these therapeutic effects. This therapeutic strategy is convenient and feasible for clinical applications by an endovascular approach; therefore, it represents a promising candidate to attenuate I/R injury after tissue plasminogen activator thrombolysis and/or endovascular thrombectomy.

Free Research Field

脳血管障害