Risk Perception of Unruptured Intracranial Aneurysms

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592113
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Gunma University
• Principal Investigator: YOSHIMOTO Yuhei 群馬大学, 医学(系)研究科(研究院), 教授 (50242061)
• Co-Investigator(Kenkyū-buntansha): SATO Koji 群馬大学, 医学部, 助教 (60431722)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 未破裂脳動脈瘤 / 生活の質 / マルコフモデル

Outline of Final Research Achievements

Recent prospective studies have shown that the rupture rate of small unruptured intracranial aneurysms is very low. This cross sectional study enrolled 52 patients who had previously been notified of the presence of untreated unruptured aneurysms. A Markov model was constructed to simulate the natural history over time, and the age- and size-specific loss of quality-adjusted life year (QALY) caused by the aneurysms was calculated. Preference-based subjective QALY losses (PSG and PTTO) were assessed using the standard gamble (SG) and time trade-off (TTO) according to patient’s own perceptions. Calculated theoretical QALY losses were relatively small with median values of 0.4 years and 1.9% of expected lifetime. The median values of PSG and PTTO were 10.0% and 19.5%, respectively. Notification of unruptured aneurysms exerts a significant psychological burden and excessively reduces the quality of life relative to the theoretical risks.

Free Research Field

脳神経外科