The roles of mitochondria biogenesis on ischemic neuronal injury and tolerance

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592119
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: University of Yamanashi
• Principal Investigator: KINOUCHI Hiroyuki 山梨大学, 総合研究部, 教授 (30241623)
• Co-Investigator(Kenkyū-buntansha): YOSHIOKA Hideyuki 山梨大学, 総合研究部, 助教 (20402076) ; YAGI Takashi 山梨大学, 総合研究部, 助教 (90345702)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脳虚血耐性 / ミトコンドリアバイオジェネシス

Outline of Final Research Achievements

Mitochondria play a pivotal role not only in energy production but also in cell death. In addition, recent studies have revealed that mitochondria are remarkably dynamic organelles that migrate, divide and fuse. Much attention has been paid to this phenomenon, called mitochondria biogenesis, in connection with various diseases. In this study, we elucidated the roles of mitochondria injury and biogenesis in ischemic neuronal injury and ischemic tolerance. Our results suggest that the expression change of mitochondria biogenesis related protein would lead apoptosis after ischemia, and mitochondria fusion might be associated with acquisition of ischemic tolerance.

Free Research Field

医歯薬学