Imaging of carotid vulnerable plaque using near infra red light

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592123
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kyoto University
• Principal Investigator: ISHII Akira 京都大学, 医学(系)研究科(研究院), 助教 (30467469)
• Co-Investigator(Kenkyū-buntansha): 岡田 英史 慶應義塾大学, 理工学部 (40221840)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 動脈硬化 / プラーク / 近赤外線

Outline of Final Research Achievements

The purpose of the present study is to visualize atherosclerotic plaque using near infrared spectogram. First, we attempted to image lipid embbeded in the subcutaneous tissue in rabbit. Due to remarkable diffusion noise, enough signal was not able to be obtained. Then, we switched from absorbtion to reflection light to minimize diffusion noise. Abdominal aorta in WHHL rabbit was exposed. Atherosclerotid plaque was clearly visualized using reflection infrared light spectrogram. Imaging using absolute absorbtion value at 1658 and 1714nm caused significant noise from adjacent tissue. We successfully minimized the noise using the ratio between absorbtion values at these two wave lengths.

Free Research Field

脳神経外科