2014 Fiscal Year Final Research Report
Pituitary regeneration by bone marrow stromal cell tranplantation
| Project/Area Number |
24592127
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOHMURA Eiji 神戸大学, 医学研究科, 教授 (30225388)
HOSODA Kohkichi 神戸大学, 医学研究科, 准教授 (90403261)
KONDOH Takeshi 神戸大学, 医学研究科, 医学研究員 (50273769)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 実験脳外科学 / 下垂体機能再生 / 動物モデル / 濾胞星細胞 |
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| Outline of Final Research Achievements |
The partial pituitary injury model in the rat was established with the topical application of the tetradecanoylphorbol acetate (TPA). The pituitary function in this model was mainly impaired at the GH/IGF-1 axis. Histological investigation demonstrated increased number of Ki-67 positive cells in the intermediate and anterior lobe of the pituitary gland. The number of the Sox2 positive cells were also increased, which demonstrated co-expression of S-100. This provided some evidence that the follicle satellite cells were responsible for maintenance and recovery of pituitary function.
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| Free Research Field |
医師薬学
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