2014 Fiscal Year Final Research Report
The Mechanism of the Cerebral Vasospasm: Mechanistic role for ATP-binding casscette transporter A1-mediated cholesterol metabolism
Project/Area Number |
24592130
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cerebral neurosurgery
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Research Institution | Yamaguchi University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SHIRAO Satoshi 山口大学, 大学院医学系研究科, 助教 (70448281)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | cholesterol / cerebral vasospasm / subarachnoid hemorrhage / ABCA1 |
Outline of Final Research Achievements |
Rho-kinase(ROK)-mediated vascular smooth muscle(VSM) contraction plays a pivotal role in cerebral vasospasm(CV). We previously showed that hypercholesterolemia increased sphingosylphosphorylcholine-ROK-mediated VSM contraction. In this study, we show the effect of cholesterol on CV induced by double-hemorrhage rat subarachnoid hemorrhage(SAH) model. SAH-induced basilar artery contraction was markedly reversed by intracisternal infusion with Y27632, a ROK inhibitor. Although, hypercholesterolemia increased VSM cholesterol and SAH-induced CV, depletion of VSM cholesterol by β-CD inhibited SAH-induced CV. These results indicate that cholesterol potentiates SAH-induced CV, but we could not demonstrate the mechanistic role of ATP-binding casscette transporter A1 on CV.
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Free Research Field |
脳神経外科学
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