Development of Ultra low field MRI combined MEG aimed at clinical application

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592140
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Osaka City University
• Principal Investigator: Tsuyuguchi Naohiro 大阪市立大学, 大学院医学研究科, 非常勤講師 (50295705)
• Co-Investigator(Kenkyū-buntansha): TAKAMI Toshihiro 大阪市立大学, 大学院医学研究科, 准教授 (20305626) ; ADACHI Yoshiaki 金沢工業大学, 先端電子技術応用研究所, 教授 (80308585)
• Co-Investigator(Renkei-kenkyūsha): OYAMA Daisuke 金沢工業大学, 先端電子技術応用研究所, 講師 (60569888)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 超低磁場MRI / 脳磁図 / SQUID

Outline of Final Research Achievements

The purpose of this study is to perform a basic experiment aiming clinical application of ultra-low magnetic field MRI, and further to evaluate the potential of performance improvement and its fusion of micro magnetoencephalography(MEG). In micro MEG, hardware improvements, such as reducing the distance between brain surface and sensor coil and strengthening of the shield, led to successful be clearly detect the magnetic signal from the small rat brain. In vitro, the ultra-low field MRI could detect different T1 relaxation times for tumor cells (glioma and renal cell carcinoma). In vivo, it was able to capture 2D images of rat brain. But it did not lead to obtain sufficient spatial resolution for the 3D image.
To assess independently micro MEG and ultra-low field MRI, we were able to promote the study of fusion device development to the previous step.

Free Research Field

神経生理学、脳神経外科学、医学工学