2014 Fiscal Year Final Research Report
Scientific analysis of surgical procedures by new neurophysiological monitoring that visualize neural function
| Project/Area Number |
24592154
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Nobuhito 東京大学, 医学部附属病院, 教授 (60262002)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 神経機能温存 / 神経機能モニタリング / 聴神経腫瘍 |
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| Outline of Final Research Achievements |
Improving preservation of function during the acoustic neuroma surgery is still the big issue. We have invented the following two new intraoperative neurophysiological monitoring that visualize real time neural function during the operation and applied to acoustic neuroma surgery. The first is dorsal cochlear nucleus action potential (AEDNAP) monitoring for cochlear nerve (CN). The other is root exit zone-elicited compound muscle action potential (FREMAP) monitoring for facial nerve (FN). We have applied these monitoring to over 170 acoustic neuroma cases. Ultimately we have found that both final AEDNAP amplitude preservation ratio (APR) and final FREMAP APR were associated with same-grade functional preservation. The threshold for these functional preservation of the final AEDNAP APR and final FREMAP APR were 36.5% and 61.5% respectively. We think we have developed the new surgical system that convinces the surgeons with postoperative neural function of patients during the surgery.
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| Free Research Field |
脳神経外科
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