Basic research of anti-NGF inhibitor for chronic musculoskeletal pain

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592187
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Chiba University
• Principal Investigator: KAZUHISA Takahashi 千葉大学, 医学(系)研究科(研究院), 教授 (20179477)
• Co-Investigator(Kenkyū-buntansha): OHTORI Seiji 千葉大学, 大学院医学研究院, 講師 (40361430) ; INOUE Gen 北里大学, 医学部, 准教授 (80594209) ; ORITA Sumihisa 千葉大学医学部付属病院, 材料部, 助教 (60638310)
• Co-Investigator(Renkei-kenkyūsha): MIYAGI Masayuki 北里大学, 医学部, 助教 (90627556) ; SUZUKI Miyako 千葉大学, 予防医学センター, 助教 (70734242) ; TOYONE Tomoaki 帝京大学, 溝口病院整形外科, 教授 (10407918) ; OZAWA Tomoyuki 帝京大学, 溝口病院整形外科, 講師 (60375706) ; AOKI Yasuchika 千葉大学, 大学院医学研究院, 特任教授 (70584001)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 抗NGF療法 / CGRP / ラット尾椎椎間板圧迫モデル / 椎間板性腰痛

Outline of Final Research Achievements

Create a rat caudal vertebrae intervertebral disc pressure model, we investigated the expression of calcitonin gene-related peptide (CGRP: neuropeptide involved in the inflammatory disease) in a cell body of dorsal root ganglia (DRG)to dominate the sensory nerve of the intervertebral disc. Intradiscal administration of the anti-NGF neutralizing antibodies suppressed the increased expression of CGRP of dominant sensory nerve (DRG). For the discogenic low back pain, anti-NGF therapy suggesting the potential to be effective .

Free Research Field

整形外科学