2014 Fiscal Year Final Research Report
Regulation of metastatic ability and proliferation ability of sarcoma cell by inhibition of inflammatory cytokine.
| Project/Area Number |
24592227
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANAMORI Masahiko 富山大学, 大学院医学薬学研究部(医学), 教授 (20204547)
SUZUKI Kayo 富山大学, 大学病院, 医員 (20456388)
HORI Takeshi 富山大学, 大学病院, 医員 (30401847)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 骨軟部腫瘍 / 炎症性サイトカイン / 転移機能 / 免疫機能 / 手術 |
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| Outline of Final Research Achievements |
Both IL-12 and IL-18, for as candidate inflammatory cytokine concerned with a treatment of bone soft part sarcoma, were suggested by miRNA array. These results lead the following: 1) therapeutic addition depending on condition of tumor, 2) relationships between sarcoma cell and host environment, and 3) degradation of "accompaniment fastness" by tumor resection. Furthermore, we were able to do analysis of metastatic mechanisms by miRNA array at the same time. The metastatic formations is inhibited by regulations of migration ability, invasion ability of sarcoma cell, and adhesion ability to a vascular endothelial cells in low concentration of molecular target drug. On the other hand, the ability of sarcoma cells was inhibited in high concentration of molecular target drug. These results might contribute to the control of metastatic formation.
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| Free Research Field |
骨軟部腫瘍学
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