The research of biochemical effects of early active mobilization protocol after flexor tendon repair.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592239
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: University of the Ryukyus
• Principal Investigator: FUTENMA Chojo 琉球大学, 医学(系)研究科(研究院), 助教 (20264492)
• Co-Investigator(Kenkyū-buntansha): KANAYA Fuminori 琉球大学, 医学研究科, 教授 (90233866) ; MAEHARA Hiroki 琉球大学, 医学研究科, 講師 (30510094)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 屈筋腱損傷

Outline of Final Research Achievements

Rat’s 2nd, 3rd and 4th toe flexor tendons were transected and repaired under general anesthesia. The repaired tendons were divided into 2 groups; group 1 (immobilized group): the ankle joint was maximum flexed and MTP joints were 90-degree flexion: group 2 (active mobilized group): the ankle was 0-degree flexed and the toes were permitted active flexion and extension. Tensile strength, macroscopic findings and pathological findings were evaluated on 0 or 7 or 14 or 21 or 28 days after surgery. The tensile strengths of active mobilized group were significantly greater than immobilized group on 21 and 28 days. On macroscopic, the repair sites of immobilized group were atrophic compared to active mobilized group on 21 and 28 days. On pathologic findings, the healing process of active mobilized group was earlier than immobilized group.
Extractions of RNA were failed, because there were few cells on repaired tendons. We couldn’t perform about RT - PCR or adherence gene research.

Free Research Field

整形外科学　手の外科