Bone microenvironment affects cancer progression via mesenchymal stromal cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592241
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Nara Medical University
• Principal Investigator: Kido Akira 奈良県立医科大学, 医学部, 講師 (70382306)
• Co-Investigator(Kenkyū-buntansha): IMANO Motohiro 近畿大学, 医学部, 准教授 (00278681) ; AKAHANE Manabu 奈良県立医科大学, 医学部, 准教授 (40326327) ; TANAKA Yasuhito 奈良県立医科大学, 医学部, 教授 (30316070) ; HONOKI Kanya 奈良県立医科大学, 医学部, 准教授 (40336863) ; GOJO Satoshi 京都府立医科大学, 医学部, 教授 (90316745) ; SHIMIZU Takamasa 奈良県立医科大学, 医学部, 助教 (70464667) ; UEHA Tomoyuki 奈良県立医科大学, 医学部, 研究員 (50572963)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: がん / 骨転移 / 骨微小環境 / 間葉系幹細胞 / フラクタルカイン / 近赤外蛍光内視鏡 / 骨微細構造

Outline of Final Research Achievements

Mesenchymal stem (stromal) cells play important role in cancer progression. In this study, we focused the (normal) bone microenvironment in patients with cancer. We designed in vitro and in vivo study to assess the interaction between bone marrow-derived stromal cells (BMSC) and malignant cells. We established the isolation method of BMSC from blood samples of patients, investigated bone microenvironment using the near infrared fluorescence endoscopy method, and performed coculture assays with BMDC and malignant cells.

Free Research Field

骨軟部腫瘍