Development of new adjuvant therapy using nanoparticles for malignant bone and soft tumors

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592244
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Keio University
• Principal Investigator: MORIOKA Hideo 慶應義塾大学, 医学部, 講師 (10230096)
• Co-Investigator(Kenkyū-buntansha): SUSA Michiro 慶應義塾大学, 医学部, 助教 (90327560)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 悪性骨・軟部腫瘍 / 化学療法 / ナノ粒子 / 薬剤耐性 / 分子標的治療

Outline of Final Research Achievements

Improvements in surgical technique, chemotherapy, and radiotherapy have enhanced the prognosis of patients with malignant bone and soft tissue tumors, but have since reached a plateau in recent years. Novel approaches have been sought but with limited results. On the other hand, several varieties of nanoparticles, including multifunctional nanoparticles, are available that localize the biodistribution of conventional chemotherapeutics to the tumor site. Also, nanoparticles loaded with chemotherapeutic drugs have the ability to overcome drug resistance which is a major obstacle impeding the progress of the treatment. Multifunctional nanoparticles, which have the potential to further augment the bioavailability of drugs, are being actively investigated. The purpose of this study is to investigate in vitro and in vivo therapeutic effects of multifunctional nanoparticles in malignant bone and soft tissue tumors with drug resistance for current chemotherapy.

Free Research Field

骨・軟部腫瘍、骨転移、化学療法、分子標的治療