2014 Fiscal Year Final Research Report
Analyses of innate immune sensors, TLR and NLR, in periprosthetic infection.
Project/Area Number |
24592252
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Yamagata University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
SASAKI Kan 山形大学, 医学部, 准教授 (00444034)
TAKAKUBO Yuya 山形大学, 医学部, 講師 (80431461)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 人工股関節の弛み / 自然免疫 / TLR / NLR |
Outline of Final Research Achievements |
We have demonstrated that TLR1, TLR2, TLR6 and NLRP3 expressions on macrophages, fibroblsts and neutrophils in the periprosthetic tissue from infected and aseptic loose hip joints. mRNA expression of TLR2, NLRP3, TNF-α and IL-1β on phagocytes stimulating by LTA-coating titanium particles were ehnanced, whereas, reinforced secretion of IL-1β was not detected in spite of marked release of TNF-α.
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Free Research Field |
整形外科学
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