2014 Fiscal Year Final Research Report
Roles of membrane transport protein Rab38 on bone metabolism.
| Project/Area Number |
24592255
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YASUI Tetsuro 東京大学, 医学部附属病院, 講師 (30583108)
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| Co-Investigator(Kenkyū-buntansha) |
OSHIMA Yasushi 東京大学, 医学部附属病院, 講師 (50570016)
KADONO Yuho 東京大学, 医学部附属病院, 講師 (70401065)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 破骨細胞 / Rab38 |
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| Outline of Final Research Achievements |
We picked up Rab38 gene as an osteoclast differentiating factor by analyzing changes of histone modifications during murine cell differentiation from bone marrow cell to osteoclast. Osteoclast differentiation was suppressed by Rab38 knock down with siRNA in vitro, but phenotype change was not observed in Rab38 knock out mouse in vitro. We concluded that Rab38 does not affect osteoclast differentiation by itself though it may concern in some form or other.
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| Free Research Field |
骨代謝
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