2015 Fiscal Year Final Research Report
A study of the innovative treatment for rheumatoid arthritis by regulating synoviocytes
| Project/Area Number |
24592261
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
Miura Yasushi 神戸大学, 保健学研究科, 准教授 (60346244)
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| Research Collaborator |
FUKUDA Koji
MAEDA Toshihisa
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 関節リウマチ / 滑膜線維芽細胞 |
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| Outline of Final Research Achievements |
The purpose of this study is to reveal the function of the signaling pathway with decoy receptor 3 (DR3) and its specific ligand TL1A on the synovitis of rheumatoid arthritis (RA) in order to establish a new therapy for RA. We newly found that the set of genes of which expression regulated by DcR3 on RA synovial fibroblasts by using microarray gene analysis. Further, we found that the expression of TPH1 and IL-12B(p40) was regulated by DcR3 and contributed to the pathogenesis of RA. We revealed that DcR3-TL1A signaling on RA synovial fibroblasts is a possible new treatment target of RA.
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| Free Research Field |
関節リウマチ
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