2014 Fiscal Year Final Research Report
A novel chromatin protein on aging-dependent osteoarthritis
| Project/Area Number |
24592282
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Miyazaki (2013-2014)
Tokyo Medical University (2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中島 利博 東京医科大学, 医学部, 教授 (90260752)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 変形性関節症 / 加齢 / 軟骨代謝 |
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| Outline of Final Research Achievements |
It has been reported that a chromatin protein HMGB2 is responsible for aging-dependent osteoarthritis. We succeeded to establish bone marrow-derived mesenchymal stem cells (MSC) from WT and Hmgb2-/- mice and found that a gene X is most down-regulated in Hmgb2-/- MSC. Interestingly, the knockout mice of this gene has been reported as a progeria model, showing that HMGB2-gene X cascade is deeply involved in aging phenomenon. We also found that the mice caused early osteoarthritis. In vitro study, Hmgb2-/- MSC affected not only on chondrogenesis but on osteogenesis and adipogenesis. These findings suggest that new pathways other than Wnt/beta-catenin signal might exist on articular cartilage degeneration.
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| Free Research Field |
整形外科学
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