2014 Fiscal Year Final Research Report
Analysis of orexin-receptor functions
| Project/Area Number |
24592306
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YANO Takeshi 宮崎大学, 医学部・集中治療部, 助教 (80521707)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | オレキシン / 麻酔 / 睡眠と覚醒 |
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| Outline of Final Research Achievements |
Intracerebroventricular (i.c.v.) injection of orexin A(OXA) produces an increase in blood pressure and heart rate. The cardiovascular responses induced by i.c.v.-injection of OXA were mainly mediated by OX1-receptor rather than OX2-receptor. I.c.v.-injection of OXA increased NE and Glu mediated by OX1-receptor and OX2-receptor. These responses were inhibited by propofol and sevoflurane in a concentration dependent manner, but not by dexmedetomidine and ketamine, These results suggests that OXA increase NE and Glu in the prefrontal cortex mediated by GABAA receptor.
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| Free Research Field |
麻酔科
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