Effects of inhaled anesthetic on organ blood flow during mild hypo- and hyperthermia

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592331
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: University of Fukui
• Principal Investigator: Takakura Ko 福井大学, 医学部, 准教授 (40206735)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 周術期 / 体温 / セボフルラン / ノルアドレナリン / 臓器血流

Outline of Final Research Achievements

I studied the vasoreactive changes by the autonomic nerve transmitters and the internal organ blood flow changes by the general anesthesia at mild hyper- or hypothermia using rats. The vasoreactivity to norepinephrine attenuated at mild hyperthermia and increased at mild hypothermia in most blood vessels. The internal organ blood flow did not change at mild hyperthermia under the low-concentration of inhalated anesthetic sevoflurane, but renal blood flow decreased under the high-concentration of it. These results show that the slight temperature changes in the perioperative period change vasoreactivity to the autonomic nerve and the each internal organ blood flow.

Free Research Field

麻酔学