2014 Fiscal Year Final Research Report
The antinociceptive effect of sevoflurane
| Project/Area Number |
24592359
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Masanobu 東海大学, 医学部, 准教授 (90276791)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | セボフルラン / 鎮痛効果 |
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| Outline of Final Research Achievements |
Intrathecal administration of sevoflurane induced dose-dependently （0.2-10μl）antinociceptive effects using tail flick test (ED50: 0.7 microlitter). The contents of sevoflurane was 0.9 mM in the cerebral spinal fluids of rats under sevoflurane anesthesia (1 MAC). The artificial cerebral spinal fluids containing sevoflurane (2.6 mM) induced antinociceptive effects, but not motor dysfunction.
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| Free Research Field |
麻酔科学
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