2014 Fiscal Year Final Research Report
Molecular analysis of bone metastatic pain
| Project/Area Number |
24592363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Wakayama Medical University (2013-2014)
Osaka Medical College (2012) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 癌性疼痛 / 骨転移 / 動物モデル |
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| Outline of Final Research Achievements |
Gene expression analysis was performed using by dorsal root ganglions (DRG) of rat bone metastasis model. It was revealed that matrix metalloproteinase (MMP) 13 and P2x7 receptor were up-regulated in DRG with bone metastatic microenvironment. Cytokines such as IL-1 and TNF-a, abundant in bone metastatic foci, increased the MMP13 mRNA expression in organ cultured DRG. It was considered that up-regulated MMP13 expression accelerate the osteolysis, which in turn contribute tumor progression and development of pain. In addition, it was suggested that acidic microenvironment in tumor is one of the factors, which induced the expression of P2x7 receptors in DRG.
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| Free Research Field |
実験病理学
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