Functional analysis of magnetic nanoparticles and the related gene for prostate cancer therapy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592379
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Yokohama National University
• Principal Investigator: WATANABE Masatoshi 横浜国立大学, 工学(系)研究科(研究院), 教授 (90273383)
• Co-Investigator(Kenkyū-buntansha): SHIRAISHI Taizo 三重大学, 医学(系)研究科(研究院), 教授 (30162762)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 前立腺癌 / ナノ粒子 / 抗癌剤

Outline of Final Research Achievements

Magnetite nanoparticles (MgNPs), have a unique property of superparamagnetism and reactive oxygen specimens (ROS) production, which can enhance the delivery and treatment efficiency of anti-cancer drugs. In this study, we have shown that in vitro enhanced effects of bare/surface modified MgNPs combined with docetaxel in comparison with docetaxel in prostate cancer cells via different mechanisms. In addition, effect of MgNPs on zyxin expression may be related with ROS production.

Free Research Field

腫瘍学、医工学