Investigation of molecular mechanism of FGF family involved in prostate cancer and metabolic syndrome

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592392
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Hiroshima University
• Principal Investigator: TEISHIMA Jun 広島大学, 大学院医歯薬保健学研究院, 講師 (20397962)
• Co-Investigator(Kenkyū-buntansha): MATSUBARA Akio 広島大学, 大学院医歯薬保健学研究院, 教授 (10239064) ; INOUE Shogo 広島大学, 病院, 助教 (90457177) ; SHOJI Koichi 広島大学, 病院, 助教 (90565805)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 前立腺癌 / 増殖因子 / 上皮間葉移行 / メタボリック症候群

Outline of Final Research Achievements

Serum FGF19/21 levels in high Gleason grade group was significantly higher than that in low Gleason grade group. In the immunostaining, the biochemical recurrence free survival rate in FGF19/21-positive group was lower than that in FGF21-negative group. Cell viability and the expression of EMT marker were significantly enhanced by treatment with FGF19/21 in LNCaP and PC3 cells. Our data indicate that FGF21 might be associated with biochemical recurrence by promoting cell proliferation of prostate cancer.

Free Research Field

泌尿器科学