Investigation of Mechanism of Action of Steroid Sulfatase in Bladder Cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592406
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Osaka City University
• Principal Investigator: TAMADA Satoshi 大阪市立大学, 医学(系)研究科(研究院), 講師 (20382179)
• Co-Investigator(Kenkyū-buntansha): WEI Min 大阪市立大学, 医学(系)研究科(研究院), 准教授 (70336783) ; KATO Minoru 大阪市立大学, 医学(系)研究科(研究院), 登録医 (30711684)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 膀胱癌 / 浸潤 / アンドロゲン

Outline of Final Research Achievements

we found out that steroid sulfatase (STS), an enzyme involved in androgen synthesis, is an important factor of invasion and prognosis of bladder cancer (BCa) patients. First, we demonstrated that the expression level of STS was significantly higher in muscle invasive BCa compared to non muscle-invasive BCa and the prognosis of STS positive Bca is significantly worse than that of STS negative BCa. Sedond, STS-knock down BCa cells showed less migration and invasion capability. Lastly, we showed that STS is relevant to epithelial to mesenchymal factors such as vimentin and ZEB1.
In conclusion, we showed the possibility that STS is a novel target of BCa treatment.

Free Research Field

泌尿器がん