Does Boturinum Toxin regulate TRP channel of the urinary bladder?

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592426
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: University of Yamanashi
• Principal Investigator: KUDO Shoji 山梨大学, 総合研究部, 医学研究員 (10313800)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Masayuki 山梨大学, 総合研究部, 教授 (80197318) ; MIYAMOTO Tatsuya 山梨大学, 総合研究部, 助教 (80456459) ; KIRA Satoru 山梨大学, 総合研究部, 診療助教 (10530115) ; HANEDA Yaburu 山梨大学, 総合研究部, 助教 (20402068) ; KOBAYASHI Hideki 山梨大学, 総合研究部, 助教 (50402053)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 下部尿路機能障害 / 過活動膀胱 / 排尿機能 / ＴＲＰイオンチャネル / VNUT

Outline of Final Research Achievements

ATP produced from urothelial cells have 2 functions. The 1st is to induce initial sensation of fullness of the urinary bladder, and 2nd is to improve compliance of the urinary bladder. We proved that urothelial cells can release ATP by exocytosis. This form of ATP release is regulated by VNUT (a vesicular nucleotide transporter). For example, VNUT-KO mice lack the initial sensation of fullness of the urinary bladder, reveal urinary frequent due to lower compliance of the urinary bladder than wild type, and do not urinate at similar locations as wild type. Among all parameter of urodynamic examination, only initial sensation of fullness of the urinary bladder shows a statistically significant negative correlation with quantitative expression of the urothelial cells.

Free Research Field

泌尿器科学