Lipid metabolism in preeclamptic placenta

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592469
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kyoto University
• Principal Investigator: TATSUMI Keiji 京都大学, 医学(系)研究科(研究院), 非常勤講師 (10324633)
• Co-Investigator(Kenkyū-buntansha): 近藤 英治 (10544950) ; 小西 郁生 (90192062)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 妊娠高血圧腎症 / 酸化ストレス / statin / Nrf2

Outline of Final Research Achievements

Oxidative stress and inflammation are considered to be deeply involved in preeclampsia.
The activation of Nuclear factor erythroid 2-related factor2(Nrf2),a key transcriptional regulator against oxidative stress, was significantly suppressed in preeclamptic placentas. In vitro, Nrf2 activation was suppressed under hypoxic conditions, but it was augmented by statin. Nrf2 knockdown resulted in insufficient enhancement of antioxidant and cytoprotective genes under oxidative stress. In contrast, the Nrf2 signaling was augmented by statin. Reactive oxygen species(ROS) levels were observed treated with H2O2, while statin treatment significantly attenuated the H2O2-induced ROS levels.
Statin may have a potential therapeutic role for preeclampsia.

Free Research Field

婦人科学産科学