Immunological memory induced by maternal intranasal immunization with PspA

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592557
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Wakayama Medical University
• Principal Investigator: Hotomi Muneki 和歌山県立医科大学, 医学部, 准教授 (90336892)
• Co-Investigator(Kenkyū-buntansha): HIROKA Masanobu 和歌山県立医科大学, 医学部, 助教 (80423945) ; IKEDA Yorihiko 和歌山県立医科大学, 医学部, 講師 (20423949) ; YUASA Jun 和歌山県立医科大学, 医学部, 助教 (10725550)
• Research Collaborator: KONO Masamitsu 和歌山県立医科大学, 医学部, 助教 (20511570) ; Togawa Akihisa 和歌山県立医科大学, 医学部, 講師 (70305762)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 母体免疫 / 肺炎球菌 / メモリー

Outline of Final Research Achievements

To protect pneumococcal infections during early childhood, it is important to induce and maintain effective protective immune responses against these pathogens during early childhood. In this study, we evaluated the induction of specific immune responses in offspring by breast milk from maternal immunized mother mice with with pneumococcal surface protein A.The immunological memory of specific responses in maternal-immunized offspring with PspA were observed. The current results suggested that PspA specific immune response was memorized in offspring maternal immunized with PspA for a considerable period of time. The maternal immunization would be one of the most suitable approaches to induce effective immune protections against pneumococcal infections.

Free Research Field

医歯薬学