Adaptive plasticity of otolith-ocular reflex using off-vertical axis rotation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592566
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: St. Marianna University School of Medicine
• Principal Investigator: KOIZUKA IZUMI 聖マリアンナ医科大学, 医学部, 教授 (10211228)
• Co-Investigator(Kenkyū-buntansha): MIKAMI Koshi 聖マリアンナ医科大学, 医学部, 助教 (20434409)
• Co-Investigator(Renkei-kenkyūsha): MIYAMOTO Yasuhiro 聖マリアンナ医科大学, 医学部, 助教 (70367340)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 耳科学

Outline of Final Research Achievements

The vestibulo-ocular reflex (VOR) produces compensatory eye movements during head movements. The VOR consists of the semicircular-ocular reflex (ScOR) and the otolith-ocular reflex (OOR). The VOR is under adaptive control that corrects VOR performance when visual-vestibular mismatch arises during head movements. Most experiments concerning plasticity of the VOR have used the ScOR. In this study, using an off-vertical axis rotation, we studied whether the OOR showed plastic change by visuo-vestibular conflict stimulation or not. To modify the OOR, we used an adaptation paradigm for 20 minutes. All subjects failed to show adaptive plasticity after exposure to visuo-vestibular conflict stimulation for 20 minutes. Tilt suppression may play an important role to cancel the plastic change in the OOR.

Free Research Field

耳鼻咽喉科学