2014 Fiscal Year Final Research Report
Analysis of malignant potential in high-grade salivary carcinoma
| Project/Area Number |
24592599
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TORAHIKO Nakashima 九州大学, 医学研究科, 准教授 (00284505)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 唾液腺腫瘍 / 高悪性度癌 |
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| Outline of Final Research Achievements |
In this study, we aimed to investigate the molecular mechanisms underlying the development of mucoepidermoid carcinoma (MEC). In 31 cases, we examined the MAML2 fusion status using reverse transcriptase polymerase chain reaction, and HER2 and EGFR status using immunohistochemistry and chromogenic in-situ hybridization. Our results suggest that HER2 or EGFR gene abnormality could play an important role in the development of high-grade MEC, and also in the progression from MAML2 fusion-positive low-/ intermediate-grade to high-grade in a subset of MEC. Furthermore, we suggest that high-grade MEC com- prises a heterogeneous group of tumours in terms of molecular pathogenesis, in particular MAML2 fusion status.
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| Free Research Field |
外科病理学
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