Development of cancer/testis antigen, TEX101-targeted therapy in head and neck squamous cell carcinoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592609
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Juntendo University (2013-2014); Nippon Medical School (2012)
• Principal Investigator: YOSHITAKE HIROSHI 順天堂大学, 医学(系)研究科(研究院), 非常勤講師 (00396574)
• Co-Investigator(Kenkyū-buntansha): ARAKI Yoshihiko 順天堂大学, 医学研究科, 准教授 (70250933) ; YOKOI Hidenori 杏林大学, 医学部, 准教授 (80317487)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: TEX101 / Ly6k / 癌・精巣抗原 / 頭頸部癌 / GPIアンカー型タンパク質

Outline of Final Research Achievements

A novel cancer/testis antigen, TEX101 is required for migration of spermatozoa from the uterus into the oviduct. This molecule plays a role in this biological process as an effector molecule, presumably with ADAM3. Accordingly, these experimental results suggest that TEX101 may be a regulator of cell adhesion and migration. In addition, TEX101 was associated with Ly6k on the surface of germ cells, and these molecules were co-factors that contribute to the molecular stability of TEX101/Ly6k complex. Although associate molecule(s) of TEX101 in cancer cells still remain to be unidentified, TEX101-related molecules would be potential biological markers as targets for cancer therapy.

Free Research Field

耳鼻咽喉科学